Marie was in a 15-year relationship with yoga instructor Kent Katich, which ended in September 2015. They have a daughter, Luna Marie, born in February 2009. Marie is a longtime vegetarian and raised her child as a vegetarian.

From 2011 to 2017, Marie had a starring role in the ABC Family/Freeform drama series Switched at Birth, portraying as Regina Vasquez, the birth mother of one of the girls and legal mother of the other.

In October 2007, she launched her own clothing line, “The Constance Marie Collection”. In the same year, she appeared in an ad for PETA, encouraging people to spay and neuter their pets.

Marie began her acting career when she was in her teenage years. She landed a spot in the 1988 film Salsa. Other television and film credits include Early Edition, Dirty Dancing, Selena, Spin City, and Ally McBeal. Marie was chosen for the role of Angie Lopez in the ABC comedy series George Lopez. (She is of no relation to Lopez, in spite of their common surname.) In 2001, Marie starred in the comedy-drama film Tortilla Soup alongside Héctor Elizondo, Jacqueline Obradors, and Elizabeth Peña. She also appeared in the PBS drama series American Family.

At age 19, Marie appeared as a dancer in the musical Cosmopolis by composer Ryuichi Sakamoto in Japan. When she returned to Los Angeles, she was spotted at a club by a dance choreographer for David Bowie and she was hired for the Glass Spider Tour in 1987.

Constance Marie Lopez (born September 9, 1965) is an American actress of Mexican origin. She is known for her role as Angie Lopez in George Lopez (2002–2007) and her role as Marcela Quintanilla (mother of Selena) in the film Selena (1997). She portrayed Regina Vasquez in the ABC Family/Freeform drama series Switched at Birth (2011–2017). She is currently portraying Camila Diaz in the Prime Video drama series Undone (2019–present).