Sarah Tabrizi

Tabrizi is distinguished for her work on mechanisms of cellular neurodegeneration and in particular Huntington’s disease pathobiology, biomarkers, outcome measures and clinical trials. Amongst her achievements, she has identified a key role for the innate immune system in the pathogenesis of Huntington’s disease, published the first assay of the mutant HD protein in human blood cells, and designed and led two major, international, influential research initiatives, TRACK-HD and Track-On HD.

To date these studies have yielded fundamental new insights into the preclinical phase of neurodegeneration in Huntington’s disease including identifying predictors of disease onset, progression, evidence of brain compensation and plasticity and neurobiological changes occurring twenty years before predicted disease onset, and her work established a battery of clinical trial outcome measures. Recently her work identified an important new genetic modifier of disease progression in Huntington’s disease, which has opened up new avenues of research into targeting DNA repair pathways as possible therapeutics for Huntington’s disease.

As of November 2019, Tabrizi had authored over 300 publications, with over 22,000 citations for her research.

In 2017 Tabrizi was the subject of a profile article in The Lancet Neurology.

Tabrizi gave a keynote presentation at the 2016 Google Zeitgeist Minds conference about the trial, and the prospect of gene silencing for neurodegenerative disease. She was the lead Clinical Investigator for the first clinical trial of a ‘gene silencing’ or huntingtin-lowering drug in Huntington’s disease patients. The announcement of the ‘top line’ results from the Phase 1b/2a safety trial in December 2017 received widespread national and international media coverage and was covered in features by BBC News, Guardian and Nature. In May 2019 the full results were published in The New England Journal of Medicine.

Tabrizi graduated with a first-class degree in biochemistry from Heriot-Watt University in 1986 and an MB ChB from the University of Edinburgh in 1992, where she graduated with the Gold Medal (Ettles Scholar) for the most distinguished medical graduate. She obtained a PhD at University College London in 2000. During her time as a trainee neurologist at the National Hospital for Neurology and Neurosurgery (NHNN), Queen Square, Sarah worked for Professors Anita Harding and David Marsden, both of whom would make a lasting impression on her.

She undertook an MRC Clinical Training Fellowship PhD studying mitochondrial dysfunction in neurodegeneration with Tony Schapira and Gillian Bates from 1996-1999 then obtained a Department of Health National Clinician Scientist Fellowship at the UCL Institute of Neurology in 2002 to work with John Collinge and Charles Weissmann. She was promoted to UCL Clinical Senior Lecturer and Honorary Consultant Neurologist in 2003, to Reader in 2007 and Full Professor in 2009.

Sarah Joanna Tabrizi FMedSci (born 26 September 1965) is a British-Iranian neurologist and neuroscientist in the field of neurodegeneration, particularly Huntington’s disease. She is a Professor and Joint Head of the Department of Neurodegenerative Diseases at the UCL Institute of Neurology; the founder and Director of the UCL Huntington’s Disease Centre; a Principal Investigator at the UK Dementia Research Institute at UCL; and an Honorary Consultant Neurologist at the National Hospital for Neurology and Neurosurgery, Queen Square, London, where she established the Multidisciplinary Huntington’s Disease Clinic. The UCL Huntington’s Disease Centre was officially opened on 1 March 2017 by UCL President and Provost Professor Michael Arthur.

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